Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Molecular mechanisms of dietary restriction promoting health and longevity

CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022 - nature.com
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

[HTML][HTML] Sirtuin signaling in cellular senescence and aging

SH Lee, JH Lee, HY Lee, KJ Min - BMB reports, 2019 - ncbi.nlm.nih.gov
Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …

[HTML][HTML] Cellular senescence in cardiovascular diseases: a systematic review

C Hu, X Zhang, T Teng, ZG Ma, QZ Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Senescence mechanisms and targets in the heart

MS Chen, RT Lee, JC Garbern - Cardiovascular research, 2022 - academic.oup.com
Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

The aging cardiovascular system: understanding it at the cellular and clinical levels

F Paneni, C Diaz Cañestro, P Libby, TF Lüscher… - Journal of the American …, 2017 - jacc.org
Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers,
and health systems. Structural and functional alterations of vessels accumulate throughout …

Ageing, metabolism and cardiovascular disease

S Costantino, F Paneni… - The Journal of physiology, 2016 - Wiley Online Library
Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …

SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection

N D'Onofrio, L Servillo, ML Balestrieri - Antioxidants & redox …, 2018 - liebertpub.com
Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Arterial ageing: from endothelial dysfunction to vascular calcification

M Tesauro, A Mauriello, V Rovella… - Journal of internal …, 2017 - Wiley Online Library
Complex structural and functional changes occur in the arterial system with advancing age.
The aged artery is characterized by changes in micro RNA expression patterns, autophagy …

MicroRNA key to angiogenesis regulation: MiRNA biology and therapy

A Tiwari, B Mukherjee, M Dixit - Current cancer drug targets, 2018 - ingentaconnect.com
Angiogenesis is involved in maintaining normal physiological processes like embryonic
development, wound healing, inflammation and reproduction. Pathogenesis of various …