Ion channels in cancer: are cancer hallmarks oncochannelopathies?
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …
all cancer cell genotypes generally translate into several common pathophysiological …
Role of ion channels and transporters in cell migration
A Schwab, A Fabian, PJ Hanley… - Physiological …, 2012 - journals.physiology.org
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …
cell in the body that is not motile at a given point in its life cycle. Important physiological …
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
Increases in cytosolic free Ca2+ ([Ca2+] i) represent a ubiquitous signalling mechanism that
controls a variety of cellular processes, including proliferation, metabolism and gene …
controls a variety of cellular processes, including proliferation, metabolism and gene …
Calcium and cancer: targeting Ca2+ transport
Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …
Ion channels and the hallmarks of cancer
Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …
Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?
N Prevarskaya, H Ouadid-Ahidouch… - … of the Royal …, 2014 - royalsocietypublishing.org
Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …
migration. Calcium ions are central to these phenomena, serving as major signalling agents …
[HTML][HTML] TRP channels in cancer
N Prevarskaya, L Zhang, G Barritt - … Acta (BBA)-Molecular Basis of Disease, 2007 - Elsevier
The progression of cells from a normal differentiated state in which rates of proliferation and
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …
[HTML][HTML] Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration
N Déliot, B Constantin - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The study of calcium channels in molecular mechanisms of cancer transformation is still a
novel area of research. Several studies, mostly conducted on cancer cell lines, however …
novel area of research. Several studies, mostly conducted on cancer cell lines, however …
High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters
I Dhennin-Duthille, M Gautier, M Faouzi… - Cellular Physiology and …, 2011 - karger.com
Abstract Background: Transient Receptor Potential (TRP) channels are expressed in many
solid tumors. However, their expression in breast cancer remains largely unknown. Here, we …
solid tumors. However, their expression in breast cancer remains largely unknown. Here, we …
Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer
ORAI family channels have emerged as important players in malignant transformation, yet
the way in which they reprogram cancer cells remains elusive. Here we show that the …
the way in which they reprogram cancer cells remains elusive. Here we show that the …