Vitiligo: a review

C Bergqvist, K Ezzedine - Dermatology, 2020 - karger.com
Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of
the population worldwide. The disease is characterized by the selective loss of melanocytes …

Update on the pathogenesis of vitiligo

HZ Marchioro, CCS Castro, VM Fava… - Anais brasileiros de …, 2022 - SciELO Brasil
Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

V Orrù, M Steri, C Sidore, M Marongiu, V Serra, S Olla… - Nature …, 2020 - nature.com
We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …

Revisiting IL-2: Biology and therapeutic prospects

AK Abbas, E Trotta, D R. Simeonov, A Marson… - Science …, 2018 - science.org
Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell
growth factor essential for the proliferation of T cells and the generation of effector and …

Mechanisms of melanocyte death in vitiligo

J Chen, S Li, C Li - Medicinal Research Reviews, 2021 - Wiley Online Library
Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …

Vitiligo: a focus on pathogenesis and its therapeutic implications

C Bergqvist, K Ezzedine - The Journal of dermatology, 2021 - Wiley Online Library
Vitiligo is the most common depigmenting disorder affecting 0.1%–2% of the population
worldwide. The characteristic white patches result from the selective loss of melanocytes …

Vitiligo, from pathogenesis to therapeutic advances: state of the art

F Diotallevi, H Gioacchini, E De Simoni… - International Journal of …, 2023 - mdpi.com
Vitiligo is an acquired hypopigmentation of the skin due to a progressive selective loss of
melanocytes; it has a prevalence of 1–2% and appears as rounded, well-demarcated white …

Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants

Y **, G Andersen, D Yorgov, TM Ferrara, S Ben… - Nature …, 2016 - nature.com
Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of
melanocytes, with epidemiological association with other autoimmune diseases. In previous …

Vitiligo treatments: review of current therapeutic modalities and JAK inhibitors

KN Cunningham, D Rosmarin - American journal of clinical dermatology, 2023 - Springer
Vitiligo is a chronic autoimmune disease characterized by loss of pigment of the skin,
affecting 0.5–2% of the population worldwide. It can have a significant impact on patients' …

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

MA Rivas, M Beaudoin, A Gardet, C Stevens… - Nature …, 2011 - nature.com
More than 1,000 susceptibility loci have been identified through genome-wide association
studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of …