Many proteins exert their function by switching among different structures. Knowing the
conformational ensembles affiliated with these states is critical to elucidate key mechanistic …

Proteins exist as dynamic conformational ensembles. Here we suggest that the propensities
of the conformations can be predictors of cell function. The conformational states that the …

The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …

The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …

The prediction of protein 3D structure from amino acid sequence is a computational grand
challenge in biophysics and plays a key role in robust protein structure prediction …

Metal sites in proteins are often presented in an idealized way that does not capture the
intrinsic dynamic behavior of the protein or the extrinsic factors that affect changes in the …

Abstract Zinc transporter 8 (ZnT8) is highly expressed in pancreatic beta cells, localizes to
insulin secretory granules (ISG), and regulates zinc content. ZnT8 gene polymorphisms …

Transition metal complexes are a versatile area of research in the fields of chemistry,
biochemistry, and medicine. Their unique electronic properties, reactivity patterns, and …

Zinc is an essential micronutrient that participates in a multitude of cellular and biochemical
processes. It is indispensable for normal growth and the maintenance of physiological …

Background: The human zinc transporter 8 (ZNT8), also known as the solute carrier family
30A, member 8 (SLC30A8), is a β-cell specific integral membrane protein, mainly restricted …