The lipoprotein HDL has two important roles: first, it promotes reverse cholesterol transport,
and second, it modulates inflammation. Epidemiological studies show that HDL-cholesterol …

Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …

Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with
atherosclerosis. We now examine genetic, dietary, and hormonal factors regulating TMAO …

HDL cholesterol activates endothelial cell production of the atheroprotective signaling
molecule NO, and it promotes endothelial repair. In this issue of the JCI, Besler et al. provide …

Clinical efficacy of the antiplatelet drug clopidogrel is hampered by its variable
biotransformation into the active metabolite,. The variability in the clinical response to …

Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell
membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to …

Recent studies have indicated that high-density lipoproteins (HDLs) and their major
structural protein, apolipoprotein A1 (apoA1), recovered from human atheroma are …

Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …

Globally, cardiovascular disease (CVD) is the leading cause of mortality, taking an estimated
17.9 million lives annually. Myocardial infarction and stroke account for 80% of these deaths …

Here, we show that apolipoprotein A1 (apoA1), the major protein component of high density
lipoprotein (HDL), through both innate and adaptive immune processes, potently …