The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

In the past two decades, several molecular targeted inhibitors have been developed and
evaluated clinically to improve the survival of patients with cancer. Molecular targeted …

c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth
factor, activates a wide range of different cellular signaling pathways, including those …

Recently, phage display technology has been announced as the recipient of Nobel Prize in
Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be …

Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted
into motile cells, multicellular organisms would be incapable of getting past the blastula …

Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited
kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal …

Hypoxia unleashes the invasive and metastatic potential of tumor cells by largely unknown
mechanisms. The Met tyrosine kinase, a high affinity receptor for hepatocyte growth factor …

Signaling by tyrosine kinase receptors is mediated by selective interactions between
individual Src homology 2 (SH2) domains of cytoplasmic effectors and specific …

The MET tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and
angiogenesis, thereby acting as a powerful expedient for cancer dissemination. MET can …

Malignant disease occurs when neoplastic cells abandon their primary site of accretion,
cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process …