Criticality is the singular state of complex systems poised at the brink of a phase transition
between order and randomness. Such systems display remarkable information-processing …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Consciousness has been proposed to be supported by electrophysiological patterns poised
at criticality, a dynamical regime which exhibits adaptive computational properties …

The Free Energy Principle and Active Inference Framework (FEP-AI) begins with the
understanding that persisting systems must regulate environmental exchanges and prevent …

Consciousness science is marred by disparate constructs and methodologies, making it
challenging to systematically compare theories. This foundational crisis casts doubts on the …

Psychedelic drugs, such as psilocybin and LSD, represent unique tools for researchers
investigating the neural origins of consciousness. Currently, the most compelling theories of …

Objective No current model of consciousness is univocally accepted on either theoretical or
empirical grounds, and the need for a solid unifying framework is evident. Special attention …

The study of consciousness has gained momentum in recent years by the scientific
community. In this same sense, the relationship between cognitive sciences and artificial …

Integrated information theory (IIT) describes consciousness as information integrated across
highly differentiated but irreducible constituent parts in a system. However, in a complex …

This study was based on the contemporary proposal that distinct states of consciousness are
quantifiable by neural complexity and critical dynamics. To test this hypothesis, it was aimed …