Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk;
lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these …

Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS),
because genetic predisposition only explains a fraction of the risk increase. There is strong …

Multiple sclerosis (MS) is the most frequently seen demyelinating disease, with a prevalence
that varies considerably, from high levels in North America and Europe (> 100/100,000 …

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system
underpinned by partially understood genetic risk factors and environmental triggers and …

The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …

Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …

The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …

The aim of this review is to present data from the available literature concerning CXCL9,
CXCL10 and CXCL11, as well as their receptor 3 (CXCR3) in selected diseases of the …

Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system
commonly affecting young adults. Pathologically, there are patches of inflammation …

Multiple sclerosis (MS) is the major acquired central nervous system disease of young
adults. It is a female predominant disease. Multiple aspects of MS are influenced by sex …