Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective
therapy for ocular diseases, especially for the posterior segment, has been considered as a …

Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The
overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause …

Reduced glutathione (GSH) is the most abundant non-protein endogenous thiol. It is a
ubiquitous molecule produced in most organs, but its synthesis is predominantly in the liver …

The market for neuropharmaceuticals is potentially one of the largest sectors of the global
pharmaceutical market owing to the increase in average life expectancy and the fact that …

The nine multidrug resistance proteins (MRPs) represent the major part of the 12 members
of the MRP/CFTR subfamily belonging to the 48 human ATP-binding cassette (ABC) …