The heterogeneity of Parkinson's disease (PD), ie the various clinical phenotypes,
pathological findings, genetic predispositions and probably also the various implicated …

The molecular mechanisms causing the loss of dopaminergic neurons containing
neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson's …

Parkinson's disease (PD) coincides with a dramatic loss of dopaminergic neurons within the
substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress …

J. Neurochem.(2011) 118, 939–957. Abstract Alterations of iron levels in the brain has been
observed and documented in a number of neurodegenerative disorders including …

Dopaminergic neurons of the substantia nigra selectively degenerate over the course of
Parkinson's disease. These neurons are also the most heavily pigmented cells of the brain …

Since the description of some peculiar symptoms by James Parkinson in 1817, attempts
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …

The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons
in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in …

Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of
macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is …

During aging, neuronal organelles filled with neuromelanin (a dark-brown pigment) and lipid
bodies accumulate in the brain, particularly in the substantia nigra, a region targeted in …

About 60 years ago, the discovery of a deficiency of dopamine in the nigro-striatal system
led to a variety of symptomatic therapeutic strategies to supplement dopamine and to …