Challenges in the diagnosis of Parkinson's disease
Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …
Prodromal Parkinson disease subtypes—key to understanding heterogeneity
In Parkinson disease (PD), pathological processes and neurodegeneration begin long
before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal …
before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal …
The role of histone modifications: from neurodevelopment to neurodiseases
J Park, K Lee, K Kim, SJ Yi - Signal transduction and targeted therapy, 2022 - nature.com
Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research
Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical
features, with α-synuclein pathology as the gold standard to establish the definitive …
features, with α-synuclein pathology as the gold standard to establish the definitive …
Discovery of XL01126: a potent, fast, cooperative, selective, orally bioavailable, and blood–brain barrier penetrant PROTAC degrader of leucine-rich repeat kinase 2
Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson's
disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors …
disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors …
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
H Scheiblich, F Eikens, L Wischhof, S Opitz, K Jüngling… - Neuron, 2024 - cell.com
Microglia are crucial for maintaining brain health and neuron function. Here, we report that
microglia establish connections with neurons using tunneling nanotubes (TNTs) in both …
microglia establish connections with neurons using tunneling nanotubes (TNTs) in both …
The genetics of Parkinson's disease and implications for clinical practice
JO Day, S Mullin - Genes, 2021 - mdpi.com
The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease
Proteomic studies for Alzheimer's disease (AD) are instrumental in identifying AD pathways
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …
Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Molecular genetics of Parkinson's disease: Contributions and global trends
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor
dysfunction. Aging is the greatest risk factor for develo** PD. Recent molecular genetic …
dysfunction. Aging is the greatest risk factor for develo** PD. Recent molecular genetic …