The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

The use of artificial intelligence (AI) in medicine is beginning to alter current procedures in
prevention, diagnosis, treatment, amelioration, cure of disease and other physical and …

Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Antibody-dependent enhancement (ADE) of viral entry has been a major concern for
epidemiology, vaccine development, and antibody-based drug therapy. However, the …

Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to
heterogeneous target antigen expression and outgrowth of tumors lacking the antigen …

Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …

The correct spatial distribution of proteins is vital for their function and often mis‐localization
or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas …