Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII
Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …
and steady expression of some proteins as well as the rapidly changing production of other …
3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
Small nucleolar RNAs tell a different tale
J Kufel, P Grzechnik - Trends in Genetics, 2019 - cell.com
Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …
A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription
The transcriptional termination of unstable non-coding RNAs (ncRNAs) is poorly understood
compared to coding transcripts. We recently identified ZC3H4-WDR82 (" restrictor") as …
compared to coding transcripts. We recently identified ZC3H4-WDR82 (" restrictor") as …
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6
M Schmidt, F Kluge, F Sandmeir, U Kühn… - Genes & …, 2022 - genesdev.cshlp.org
The 3′ ends of almost all eukaryotic mRNAs are generated in an essential two-step
processing reaction: endonucleolytic cleavage of an extended precursor followed by the …
processing reaction: endonucleolytic cleavage of an extended precursor followed by the …
Structural insights into the human pre-mRNA 3′-end processing machinery
Summary The mammalian pre-mRNA 3′-end-processing machinery consists of cleavage
and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and other …
and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and other …
Multiple forms and functions of premature termination by RNA polymerase II
DL Bentley - Journal of Molecular Biology, 2024 - Elsevier
Eukaryotic genomes are widely transcribed by RNA polymerase II (pol II) both within genes
and in intergenic regions. POL II elongation complexes comprising the polymerase, the DNA …
and in intergenic regions. POL II elongation complexes comprising the polymerase, the DNA …
Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription
M Russo, V Piccolo, D Polizzese… - Genes & …, 2023 - genesdev.cshlp.org
Transcription termination pathways mitigate the detrimental consequences of unscheduled
promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory …
promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory …
A direct interaction between CPF and RNA Pol II links RNA 3′ end processing to transcription
Transcription termination by RNA polymerase II (RNA Pol II) is linked to RNA 3′ end
processing by the cleavage and polyadenylation factor (CPF or CPSF). CPF contains …
processing by the cleavage and polyadenylation factor (CPF or CPSF). CPF contains …