From an engineering perspective, skeletal tissues are remarkable structures because they
are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical …

Bone's remarkable mechanical properties are a result of its hierarchical structure. The
mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's …

The mechanical properties of many materials are based on the macroscopic arrangement
and orientation of their nanostructure. This nanostructure can be ordered over a range of …

Abstract Purpose of Review While thinning of the cortices or trabeculae weakens bone, age-
related changes in matrix composition also lower fracture resistance. This review …

Micro-computed tomography (micro-CT)—a version of X-ray CT operating at high spatial
resolution—has had a considerable success for the investigation of trabecular bone micro …

We investigate the three-dimensional (3-D) organization of mineralized collagen fibrils in
human cortical bone based on synchrotron X-ray phase nano-tomography images. In …

Bone is not only a dynamic living tissue, but also a composite material with a complex
hierarchical structure, responsible for bone's remarkable functionality. However, advanced …

Small-angle X-ray scattering tensor tomography, which allows reconstruction of the local
three-dimensional reciprocal-space map within a three-dimensional sample as introduced …

Bone quality is determined by a variety of compositional, micro-and ultrastructural properties
of the mineralized tissue matrix. In contrast to X-ray-based methods, the interaction of …

Chemical composition and fibrillar organization are the major determinants of osteonal bone
mechanics. However, prominent methodologies commonly applied to investigate …