Clinical applications and therapeutic potentials of advanced nanoparticles: A comprehensive review on completed human clinical trials
RV Kumarasamy, PM Natarajan… - Frontiers in …, 2024 - frontiersin.org
Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including
more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This …
more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This …
Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier
M Beygi, F Oroojalian, S Azizi‐Arani… - Advanced Functional …, 2024 - Wiley Online Library
The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed
with tight junctions and adherent junctions that regulates the transport of various materials …
with tight junctions and adherent junctions that regulates the transport of various materials …
[HTML][HTML] Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy
Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by
metabolic imbalances and neuroinflammation, posing a formidable challenge in medicine …
metabolic imbalances and neuroinflammation, posing a formidable challenge in medicine …
Enhancement of blood–brain barrier penetration and the neuroprotective effect of resveratrol
Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the
loss of dopaminergic neurons within the substantia nigra. The specific molecular …
loss of dopaminergic neurons within the substantia nigra. The specific molecular …
Naringenin-functionalized gold nanoparticles and their role in α-synuclein stabilization
Misfolding and self-assembly of several intrinsically disordered proteins into ordered β-sheet-
rich amyloid aggregates emerged as hallmarks of several neurodegenerative disorders …
rich amyloid aggregates emerged as hallmarks of several neurodegenerative disorders …
The effects of polyvinyl alcohol-coated selenium nanoparticles on memory impairment in rats
N Hashemi-Firouzi, S Afshar, SS Asl… - Metabolic Brain …, 2022 - Springer
Some mineral elements exert beneficial neuroprotection, especially in the form of
nanoparticles. The aim of the present study was to evaluate the effects of selenium …
nanoparticles. The aim of the present study was to evaluate the effects of selenium …
Parkinson's disease: a nanotheranostic approach targeting alpha-synuclein aggregation
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that is
implicated in aging populations. As numerous developed nations are experiencing …
implicated in aging populations. As numerous developed nations are experiencing …
Role of nanoparticle-conjugates and nanotheranostics in abrogating oxidative stress and ameliorating neuroinflammation
Oxidative stress is a deteriorating condition that arises due to an imbalance between the
reactive oxygen species and the antioxidant system or defense of the body. The key reasons …
reactive oxygen species and the antioxidant system or defense of the body. The key reasons …
[HTML][HTML] Neuroprotective Effects of Functionalized Hydrophilic Carbon Clusters: Targeted Therapy of Traumatic Brain Injury in an Open Blast Rat Model
P Padmanabhan, J Lu, KC Ng, DK Srinivasan… - Biomedicines, 2024 - mdpi.com
Traumatic brain injury (TBI) causes multiple cerebrovascular disruptions and oxidative
stress. These pathological mechanisms are often accompanied by serious impairment of …
stress. These pathological mechanisms are often accompanied by serious impairment of …
[HTML][HTML] Nanomedicines targeting the inflammasome as a promising therapeutic approach for cell senescence
S Chaturvedi, Z Naseem, SF El-Khamisy… - Seminars in Cancer …, 2022 - Elsevier
Technological advancements in the present era have enhanced drug discovery and
development. Nanomedicines are valuable pharmacotherapeutic tools against several …
development. Nanomedicines are valuable pharmacotherapeutic tools against several …