Peptide receptor targeting in cancer: the somatostatin paradigm
Peptide receptors involved in pathophysiological processes represent promising therapeutic
targets. Neuropeptide somatostatin (SST) is produced by specialized cells in a large number …
targets. Neuropeptide somatostatin (SST) is produced by specialized cells in a large number …
Somatostatin, somatostatin analogs and somatostatin receptor dynamics in the biology of cancer progression
The pharmacological effects (ie, inhibition of endocrine secretion and cell proliferation)
mediated by the hormone somatostatin (SRIF) are derived from its universal high-affinity …
mediated by the hormone somatostatin (SRIF) are derived from its universal high-affinity …
Stereoselective synthesis of P-stereogenic aminophosphines: ring opening of bulky oxazaphospholidines
A highly diastereoselective and efficient synthesis of P-stereogenic bulky alkyl and aryl
aminophosphines that relies on ring opening of tert-butyl-oxazaphospholidine 2 is …
aminophosphines that relies on ring opening of tert-butyl-oxazaphospholidine 2 is …
MaxPHOS Ligand: PH/NH Tautomerism and Rhodium‐Catalyzed Asymmetric Hydrogenations
E Cristóbal‐Lecina, P Etayo, S Doran… - … synthesis & catalysis, 2014 - Wiley Online Library
MaxPHOS is an active and robust P‐stereogenic ligand for asymmetric catalysis. The
presence of an NH bridge between the two phosphine moieties allows the NH/PH …
presence of an NH bridge between the two phosphine moieties allows the NH/PH …
A tetradecapeptide somatostatin dicarba-analog: Synthesis, structural impact and biological activity
We described here the first tetradecapeptide somatostatin-analogue where the disulfide
bridge has been replaced by a carbon–carbon double bond. This analogue was prepared …
bridge has been replaced by a carbon–carbon double bond. This analogue was prepared …
Fine-tuning the [Pi]-[Pi]. Aromatic interactions in peptides: somatostatin analogues containing mesityl alanine
Going through the motions: Somatostatin analogues having greater conformational rigidity
than somatostatin have been prepared by substituting Phe residues in the native sequence …
than somatostatin have been prepared by substituting Phe residues in the native sequence …
Nickel (II) and palladium (II) complexes of the small-bite-angle P-stereogenic diphosphine ligand MaxPHOS and its monosulfide
Coordination studies of the optically pure diphosphine ligand (t-Bu) 2P (NH) P (t-
BuMe)(MaxPHOS) and its monosulfide with several Pd and Ni moieties are described …
BuMe)(MaxPHOS) and its monosulfide with several Pd and Ni moieties are described …
[HTML][HTML] Insights into structure-activity relationships of somatostatin analogs containing mesitylalanine
The non-natural amino acid mesitylalanine (2, 4, 6-trimethyl-L-phenylalanine; Msa) has an
electron-richer and a more conformationally restricted side-chain than that of its natural …
electron-richer and a more conformationally restricted side-chain than that of its natural …
Synthetic peptide analogs of somatostatin: trends in the synthesis of and prospects in the search for new anticancer drugs
AN Balaev, VN Osipov, DS Khachatryan - Pharmaceutical Chemistry …, 2015 - Springer
The native hormone somatostatin plays an important role in vivo by acting on multiple
targets via a family of five receptors to produce a broad spectrum of biological effects. Some …
targets via a family of five receptors to produce a broad spectrum of biological effects. Some …
N-Imidazolebenzyl-histidine Substitution in Somatostatin and in Its Octapeptide Analogue Modulates Receptor Selectivity and Function
J Erchegyi, R Cescato, B Waser, JE Rivier… - Journal of medicinal …, 2011 - ACS Publications
Despite 3 decades of focused chemical, biological, structural, and clinical developments,
unusual properties of somatostatin (SRIF, 1) analogues are still being uncovered. Here we …
unusual properties of somatostatin (SRIF, 1) analogues are still being uncovered. Here we …