Cancer stemness is recognized as a key component of tumor development. Previously
coined" cancer stem cells"(CSCs) and believed to be a rare population with rigid …

Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The
standard of care offers minimal clinical benefit, and most GBM patients experience tumor …

Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of
glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that …

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by invasive
behavior and a compromised immune response, presenting treatment challenges. Surgical …

Tumor-initiating cells (TICs) possess the ability to evade anti-tumor immunity, potentially
explaining many failures of cancer immunotherapy. Here, we identify CD49f as a prominent …

Glioma is a type of aggressive and incurable brain tumor. Patients with glioma are highly
resistant to all types of therapies, including immunotherapies. Epigenetic reprogramming is …

Glioblastoma (GBM) tumors are the most aggressive primary brain tumors in adults that,
despite maximum treatment, carry a dismal prognosis. GBM tumors exhibit tissue hypoxia …

Tumor-associated macrophages and microglia (TAMs) are critical for tumor progression and
therapy resistance in glioblastoma (GBM), a type of incurable brain cancer. We previously …

Background Glioblastoma (GBM) is an immunosuppressive, universally lethal cancer driven
by glioblastoma stem cells (GSCs). The interplay between GSCs and immunosuppressive …

Glioblastoma (GBM) displays an infiltrative growth characteristic that recruits neighboring
normal cells to facilitate tumor growth, maintenance, and invasion into the brain. While the …