Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Solid dispersions are one of the most promising strategies to improve the oral bioavailability
of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and …

Over 40% of active pharmaceutical ingredients (API) in development pipelines are poorly
water-soluble drugs which limit formulation approaches, clinical application and …

Spray drying is a well-established manufacturing technique which can be used to formulate
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …

Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

The liquid antisolvent (LAS) precipitation process for production of ultra-fine particles has
been widely researched for a last few decades. In LAS process, precipitation of solute is …

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous
system. Solubility is one of the important parameter to achieve desired concentration of drug …

The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with
poor solubility and reasonable permeability is limited by the drug dissolution step from drug …