Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …

Proteins are major targets for radicals and two-electron oxidants in biological systems due to
their abundance and high rate constants for reaction. With highly reactive radicals damage …

Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is
symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory …

Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM)
and this appears to underlie the development of cardiovascular disease, T2DM and diabetic …

Photo-induced damage to proteins occurs via multiple pathways. Direct damage induced by
UVB (λ 280–320 nm) and UVA radiation (λ 320–400 nm) is limited to a small number of …

抄録 There is considerable interest in the role that mammalian heme peroxidase enzymes,
primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide …

Antioxidants are among the most popular health-protecting products, sold worldwide without
prescription. Indeed, there are many reports showing the benefits of antioxidants but only a …

Life on Earth evolved in the presence of hydrogen peroxide, and other peroxides also
emerged before and with the rise of aerobic metabolism. They were considered only as toxic …

Background and purpose: Growing evidence advocates that upregulation of toll-like receptor
4 (TLR4) has been suggested as a causative influence in the development and …

Parkinson's disease (PD) is a movement disorder with widespread neurodegeneration in the
brain. Significant oxidative, reductive, metabolic, and proteotoxic alterations have been …