Discoveries in structure and physiology of mechanically activated ion channels

JM Kefauver, AB Ward, A Patapoutian - Nature, 2020 - nature.com
The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Stress-induced electrolyte leakage: the role of K+-permeable channels and involvement in programmed cell death and metabolic adjustment

V Demidchik, D Straltsova, SS Medvedev… - Journal of …, 2014 - academic.oup.com
Electrolyte leakage accompanies plant response to stresses, such as salinity, pathogen
attack, drought, heavy metals, hyperthermia, and hypothermia; however, the mechanism and …

Piezo1 channels are inherently mechanosensitive

R Syeda, MN Florendo, CD Cox, JM Kefauver… - Cell reports, 2016 - cell.com
The conversion of mechanical force to chemical signals is critical for many biological
processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels …

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

CD Cox, C Bae, L Ziegler, S Hartley… - Nature …, 2016 - nature.com
Mechanosensitive ion channels are force-transducing enzymes that couple mechanical
stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is …

Visualization of the mechanosensitive ion channel MscS under membrane tension

Y Zhang, C Daday, RX Gu, CD Cox, B Martinac… - Nature, 2021 - nature.com
Mechanosensitive channels sense mechanical forces in cell membranes and underlie many
biological sensing processes,–. However, how exactly they sense mechanical force remains …

[HTML][HTML] Calcium-dependent regulation of photosynthesis

AK Hochmal, S Schulze, K Trompelt… - Biochimica et Biophysica …, 2015 - Elsevier
The understanding of calcium as a second messenger in plants has been growing
intensively over the last decades. Recently, attention has been drawn to the organelles …

Plant mechanosensitive ion channels: an ocean of possibilities

D Basu, ES Haswell - Current opinion in plant biology, 2017 - Elsevier
Highlights•Mechanosensitive ion channels are capable of transducing force into ion
flux.•Three families of plant MS channels are described to date and many more likely …

Mechanisms and physiological roles of K+ efflux from root cells

V Demidchik - Journal of plant physiology, 2014 - Elsevier
Potassium is the most abundant macronutrient, which is involved in a multitude of
physiological processes. Potassium uptake in roots is crucial for plants; however, K+ efflux …

Bacterial mechanosensors

CD Cox, N Bavi, B Martinac - Annual review of physiology, 2018 - annualreviews.org
Bacteria represent one of the most evolutionarily successful groups of organisms to inhabit
Earth. Their world is awash with mechanical cues, probably the most ancient form of which …

The role of lipids in mechanosensation

C Pliotas, ACE Dahl, T Rasmussen… - Nature structural & …, 2015 - nature.com
The ability of proteins to sense membrane tension is pervasive in biology. A higher-
resolution structure of the Escherichia coli small-conductance mechanosensitive channel …