Superoxide dismutases (SODs) constitute a very important antioxidant defense against
oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive …

Tight regulation of inflammation is very important to guarantee a balanced immune response
without develo** chronic inflammation. One of the major mediators of the resolution of …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

With their growing production and application, engineered nanoparticles (NPs) are
increasingly discharged into the environment. The released NPs can potentially interact with …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Accurate DNA replication and repair is essential for proper development, growth and tumor-
free survival in all multicellular organisms. A key requirement for the maintenance of …

The TIGAR protein has antioxidant activity that supports intestinal tissue repair and
adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we …

Abstract Beckman, Kenneth B., and Bruce N. Ames. The Free Radical Theory of Aging
Matures. Physiol. Rev. 78: 547–581, 1998.—The free radical theory of aging, conceived in …

Reactive oxygen species (ROS) are highly reactive molecules that arise from a number of
cellular sources, including oxidative metabolism in mitochondria. At low levels they can be …

Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …