Biopolymer nanoparticles for nose-to-brain drug delivery: A new promising approach for the treatment of neurological diseases
Diseases affecting the central nervous system (CNS) are among the most disabling and the
most difficult to cure due to the presence of the blood–brain barrier (BBB) which represents …
most difficult to cure due to the presence of the blood–brain barrier (BBB) which represents …
Molecular Trojan Horses for treating lysosomal storage diseases
Lysosomal storage diseases (LSDs) are caused by monogenic mutations in genes encoding
for proteins related to the lysosomal function. Lysosome plays critical roles in molecule …
for proteins related to the lysosomal function. Lysosome plays critical roles in molecule …
Room-Temperature Phosphorescence and Cellular Phototoxicity Activated by Triplet Dynamics in Aggregates of Push–Pull Phenothiazine-Based Isomers
In this study, we report a comprehensive time-resolved spectroscopic investigation of the
excited-state deactivation mechanism in three push–pull isomers characterized by a …
excited-state deactivation mechanism in three push–pull isomers characterized by a …
Evidence of Lysosomal β-Hexosaminidase Enzymatic Activity Associated with Extracellular Vesicles: Potential Applications for the Correction of Sandhoff Disease
Extracellular vesicles (EVs) can be isolated from biological fluids and cell culture medium.
Their nanometric dimension, relative stability, and biocompatibility have raised considerable …
Their nanometric dimension, relative stability, and biocompatibility have raised considerable …
Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions
Dementia in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's
disease (PD), and dementia with Lewy bodies (DLB) is a progressive neurological condition …
disease (PD), and dementia with Lewy bodies (DLB) is a progressive neurological condition …
[HTML][HTML] Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks
Microplastics (MPs) are widespread environmental pollutants that have drawn significant
attention due to their possible health risks to humans and animals, as well as their extensive …
attention due to their possible health risks to humans and animals, as well as their extensive …
Amphiphilicity-Controlled Localization of Red Emitting Bicationic Fluorophores in Tumor Cells Acting as Bio-Probes and Anticancer Drugs
A Cesaretti, L Mencaroni, C Bonaccorso, V Botti… - Molecules, 2022 - mdpi.com
Small organic molecules arouse lively interest for their plethora of possible biological
applications, such as anticancer therapy, for their ability to interact with nucleic acids, or …
applications, such as anticancer therapy, for their ability to interact with nucleic acids, or …
Targeted Sequencing of HEXA Gene Shows Missense Substitution (p.Arg499His) in a Large Pakistani Family with Tay-Sachs Disease
FK Bazai, MU Hassan, H Tayyab, S Naudhani… - Cytology and …, 2024 - Springer
Tay-Sachs disease or GM2 gangliosidosis, is caused by a deficiency of beta-
hexosaminidase A (HEXA), resulting in lysosomal accumulation of GM2 ganglioside …
hexosaminidase A (HEXA), resulting in lysosomal accumulation of GM2 ganglioside …