Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Proteases, including intracellular proteases, play roles at many different stages of malignant
progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of …

Introduction: Cathepsin B is of significant importance to cancer therapy as it is involved in
various pathologies and oncogenic processes in humans. Numerous studies have shown …

The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Albumin is derived from human or animal blood, and its ability to bind to a large number of
endogenous or exogenous biomolecules makes it an ideal drug carrier. As a result, albumin …

Communication between the cell and its surrounding environment, consisting of
proteinaceous (non-living material) and extracellular matrix (ECM), is important for …

Background Recently, the distinction between left-and right-sided colon cancer (LCC and
RCC) has been brought into focus. RCC is associated with an inferior overall survival and …

The epithelial to mesenchymal transition (EMT) program is a crucial component in the
processes of morphogenesis and embryonic development. The transition of epithelial to …

Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a
matricellular protein which regulates cell adhesion, extracellular matrix production, growth …