Develo** diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …

Microfluidics has recently emerged as a powerful tool in generation of submillimeter-sized
cell aggregates capable of performing tissue-specific functions, so-called microtissues, for …

Self-organizing neural organoids represent a promising in vitro platform with which to model
human development and disease,,,–. However, organoids lack the connectivity that exists in …

Recent advances in human stem cell-derived brain organoids promise to replicate critical
molecular and cellular aspects of learning and memory and possibly aspects of cognition in …

Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …

Realizing the full utility of brain organoids to study human development requires
understanding whether organoids precisely replicate endogenous cellular and molecular …

Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
develo** sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …

Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy,
long-QT syndrome and other neuropsychiatric conditions. TS type 1 (TS1) is caused by a …

Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …

The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …