Blood biomarkers have been considered tools for the diagnosis, prognosis, and monitoring
of Alzheimer's disease (AD). Although amyloid-β peptide (Aβ) and tau are primarily blood …

Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases …

Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely
overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Abstract See Schott and Fox (doi: 10.1093/brain/awv405) for a scientific commentary on this
article. Alzheimer's disease is a multifactorial dementia disorder characterized by early …

Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer's disease (AD)
patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic …

Clinical PET studies using 18F-THK5351 have demonstrated significant tracer retention in
sites susceptible to tau burden in Alzheimer disease (AD). However, the in vivo PET signal …

Studying autosomal dominant Alzheimer's disease (ADAD), caused by gene mutations
yielding nearly complete penetrance and a distinct age of symptom onset, allows …

Reactive astrocytes play an important role in the development of Alzheimer's disease (AD).
Here, we aimed to investigate the temporospatial relationships among monoamine oxidase …