Molecular pathways of nonalcoholic fatty liver disease development and progression
F Bessone, MV Razori, MG Roma - Cellular and Molecular Life Sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
Non-alcoholic fatty liver disease (NAFLD)–pathogenesis, classification, and effect on drug metabolizing enzymes and transporters
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
AR Mridha, A Wree, AAB Robertson, MM Yeh… - Journal of …, 2017 - Elsevier
Background & Aims NOD-like receptor protein 3 (NLRP3) inflammasome activation occurs in
Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor …
Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor …
CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload
CYP2E1 is one of the fifty-seven cytochrome P450 genes in the human genome and is
highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively …
highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively …
Recent insights into the pathogenesis of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …
Nonalcoholic fatty liver disease: pathogenesis and disease spectrum
T Hardy, F Oakley, QM Anstee… - Annual review of …, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …
the Western world and is increasing owing to its close association with obesity and insulin …
History of nonalcoholic fatty liver disease
Based on the assumption that characterizing the history of a disease will help in improving
practice while offering a clue to research, this article aims at reviewing the history of …
practice while offering a clue to research, this article aims at reviewing the history of …
A review of the molecular mechanisms of hyperglycemia‐induced free radical generation leading to oxidative stress
The prevalence of diabetes is growing worldwide with an increasing morbidity and mortality
associated with the development of diabetes complications. Free radical production is a …
associated with the development of diabetes complications. Free radical production is a …
[HTML][HTML] The interaction of hepatic lipid and glucose metabolism in liver diseases
LP Bechmann, RA Hannivoort, G Gerken… - Journal of …, 2012 - Elsevier
It is widely known that the liver is a central organ in lipogenesis, gluconeogenesis and
cholesterol metabolism. However, over the last decades, a variety of pathological conditions …
cholesterol metabolism. However, over the last decades, a variety of pathological conditions …
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …