Leishmaniasis in humans: drug or vaccine therapy?

M Ghorbani, R Farhoudi - Drug design, development and therapy, 2017 - Taylor & Francis
Leishmania is an obligate intracellular pathogen that invades phagocytic host cells.
Approximately 30 different species of Phlebotomine sand flies can transmit this parasite …

Advances in leishmaniasis

HW Murray, JD Berman, CR Davies, NG Saravia - The Lancet, 2005 - thelancet.com
Governed by parasite and host factors and immunoinflammatory responses, the clinical
spectrum of leishmaniasis encompasses subclinical (inapparent), localised (skin lesions) …

The immunology of susceptibility and resistance to Leishmania major in mice

D Sacks, N Noben-Trauth - Nature reviews immunology, 2002 - nature.com
Established models of T-helper-2-cell dominance in BALB/c mice infected with Leishmania
major—involving the early production of interleukin-4 by a small subset of Leishmania …

The leishmaniases as emerging and reemerging zoonoses

RW Ashford - International journal for parasitology, 2000 - Elsevier
The 20 or so species of Leishmania which have been recorded as human infections are all
either zoonotic, or have recent zoonotic origins. Their distribution is determined by that of …

[HTML][HTML] Status of vaccine research and development of vaccines for leishmaniasis

PM Gillespie, CM Beaumier, U Strych, T Hayward… - Vaccine, 2016 - Elsevier
A number of leishmaniasis vaccine candidates are at various stages of pre-clinical and
clinical development. Leishmaniasis is a vector-borne neglected tropical disease (NTD) …

Sex-associated hormones and immunity to protozoan parasites

CW Roberts, W Walker, J Alexander - Clinical microbiology …, 2001 - journals.asm.org
Numerous epidemiological and clinical studies have noted differences in the incidence and
severity of parasitic diseases between males and females. Although in some instances this …

Leishmaniasis: current status of vaccine development

E Handman - Clinical microbiology reviews, 2001 - journals.asm.org
Leishmaniae are obligatory intracellular protozoa in mononuclear phagocytes. They cause a
spectrum of diseases, ranging in severity from spontaneously healing skin lesions to fatal …

Vaccines to prevent leishmaniasis

R Kumar, C Engwerda - Clinical & translational immunology, 2014 - Wiley Online Library
Leishmaniasis is a parasitic disease that encompasses a range of clinical manifestations
affecting people in tropical and subtropical regions of the world. Epidemiological and …

Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites

R Hadighi, M Mohebali, P Boucher, H Hajjaran… - PLoS …, 2006 - journals.plos.org
Background Recent circumstantial evidence suggests that an increasing number of Iranian
patients with cutaneous leishmaniasis are unresponsive to meglumine antimoniate …

[HTML][HTML] Cutaneous leishmaniasis: recognition and treatment

WH Markle, K Makhoul - American family physician, 2004 - aafp.org
Cutaneous Leishmaniasis: Recognition and Treatment | AAFP Advertisement search close
brand logo WILLIAM H. MARKLE, MD, AND KHALDOUN MAKHOUL, MD Am Fam Physician …