Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
Alternative splicing and evolution: diversification, exon definition and function
H Keren, G Lev-Maor, G Ast - Nature Reviews Genetics, 2010 - nature.com
Over the past decade, it has been shown that alternative splicing (AS) is a major mechanism
for the enhancement of transcriptome and proteome diversity, particularly in mammals …
for the enhancement of transcriptome and proteome diversity, particularly in mammals …
Taming transposable elements in vertebrates: from epigenetic silencing to domestication
Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …
known to date. Because their expression and mobility can lead to genomic instability …
Regulation of alternative splicing through coupling with transcription and chromatin structure
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …
genetic information from DNA to proteins by expanding the coding capacity of genomes …
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer
ContextGenetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to
the care of women with a severe family history of breast or ovarian cancer, but an unknown …
the care of women with a severe family history of breast or ovarian cancer, but an unknown …
How did alternative splicing evolve?
G Ast - Nature Reviews Genetics, 2004 - nature.com
Alternative splicing creates transcriptome diversification, possibly leading to speciation. A
large fraction of the protein-coding genes of multicellular organisms are alternatively spliced …
large fraction of the protein-coding genes of multicellular organisms are alternatively spliced …
Genome-wide discovery of human splicing branchpoints
During the splicing reaction, the 5′ intron end is joined to the branchpoint nucleotide,
selecting the next exon to incorporate into the mature RNA and forming an intron lariat …
selecting the next exon to incorporate into the mature RNA and forming an intron lariat …
Inviting instability: transposable elements, double-strand breaks, and the maintenance of genome integrity
The ubiquity of mobile elements in mammalian genomes poses considerable challenges for
the maintenance of genome integrity. The predisposition of mobile elements towards …
the maintenance of genome integrity. The predisposition of mobile elements towards …
Alu elements as regulators of gene expression
J Häsler, K Strub - Nucleic acids research, 2006 - academic.oup.com
Alu elements are the most abundant repetitive elements in the human genome; they
emerged 65 million years ago from a 5′ to 3′ fusion of the 7SL RNA gene and amplified …
emerged 65 million years ago from a 5′ to 3′ fusion of the 7SL RNA gene and amplified …