Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

E Karbassi, A Fenix, S Marchiano, N Muraoka… - Nature Reviews …, 2020 - nature.com
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

ROS and diseases: Role in metabolism and energy supply

S Yang, G Lian - Molecular and cellular biochemistry, 2020 - Springer
Researches dedicated to reactive oxygen species (ROS) had been performed for decades,
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

Brown University TDA Wang Siyuan (Steven) 34… - Nature aging, 2022 - nature.com
Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic
and metabolic changes, and a proinflammatory senescence-associated secretory …

Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

M Ogrodnik - Aging cell, 2021 - Wiley Online Library
The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …