The mitochondrial pyruvate dehydrogenase complex (PDC) irreversibly decarboxylates
pyruvate to acetyl coenzyme A, thereby linking glycolysis to the tricarboxylic acid cycle and …

Cancer poses a serious health problem in society and is increasingly surpassing
cardiovascular disease as the leading cause of mortality in the United States. Current …

The hedgehog (Hh) pathway plays a key role in embryonic development and stem cell
programs. Deregulation of the Hh pathway is a key driver of basal cell carcinoma, and …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

ABSTRACT Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor
regulated by hypusination, a unique posttranslational modification catalyzed by …

Introduction Medulloblastoma (MB) is a heterogeneous tumor of the cerebellum that is
divided into four main subgroups with distinct molecular and clinical features. Sonic …

The revolution in cancer genomics has uncovered a variety of clinically relevant mutations in
primary brain tumours, creating an urgent need to develop non-invasive imaging biomarkers …

Abstract The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development
and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant …

Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer
therapy because its aberrant activation is implicated in several cancers. Major progress has …

The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but
its mechanism of action remains elusive. Using Shh medulloblastoma as model, we show …