Atrial fibrillation: pathogenesis, predisposing factors, and genetics

M Sagris, EP Vardas, P Theofilis… - International journal of …, 2021‏ - mdpi.com
Atrial fibrillation (AF) is the most frequent arrhythmia managed in clinical practice, and it is
linked to an increased risk of death, stroke, and peripheral embolism. The Global Burden of …

Cardiovascular risk factors and physical activity for the prevention of cardiovascular diseases in the elderly

L Ciumărnean, MV Milaciu, V Negrean… - International Journal of …, 2021‏ - mdpi.com
Cardiovascular diseases create an important burden on the public health systems,
especially in the elderly, mostly because this group of patients frequently suffer from multiple …

[HTML][HTML] Oxidative stress in cardiovascular diseases: still a therapeutic target?

T Senoner, W Dichtl - Nutrients, 2019‏ - mdpi.com
Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic
mechanisms and increased oxidative stress has been viewed as one of the potential …

Cardiovascular risks associated with gender and aging

JL Rodgers, J Jones, SI Bolleddu… - Journal of …, 2019‏ - mdpi.com
The aging and elderly population are particularly susceptible to cardiovascular disease. Age
is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are …

Alzheimer's‐like signaling in brains of COVID‐19 patients

S Reiken, L Sittenfeld, H Dridi, Y Liu… - Alzheimer's & …, 2022‏ - Wiley Online Library
Introduction The mechanisms that lead to cognitive impairment associated with COVID‐19
are not well understood. Methods Brain lysates from control and COVID‐19 patients were …

Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020‏ - ahajournals.org
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

The machineries, regulation and cellular functions of mitochondrial calcium

C Giorgi, S Marchi, P Pinton - Nature reviews Molecular cell biology, 2018‏ - nature.com
Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Protective effects of estrogen on cardiovascular disease mediated by oxidative stress

D **ang, Y Liu, S Zhou, E Zhou… - Oxidative medicine and …, 2021‏ - Wiley Online Library
Perimenopause is an important stage of female senescence. Epidemiological investigation
has shown that the incidence of cardiovascular disease in premenopausal women is lower …

Senescent cells: a therapeutic target in cardiovascular diseases

M Suda, KH Paul, T Minamino, JD Miller, A Lerman… - Cells, 2023‏ - mdpi.com
Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Mitochondrial calcium overload is a key determinant in heart failure

G Santulli, W **e, SR Reiken, AR Marks - Proceedings of the National …, 2015‏ - pnas.org
Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation–
contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP …