The intricate dance of post-translational modifications in the rhythm of life
Endogenous biological rhythms with approximately 24-h periodicity are generated by the
circadian clock, in which clock genes coordinate with one another and form a transcriptional …
circadian clock, in which clock genes coordinate with one another and form a transcriptional …
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …
The emerging role for Cullin 4 family of E3 ligases in tumorigenesis
As a member of the Cullin-RING ligase family, Cullin-RING ligase 4 (CRL4) has drawn much
attention due to its broad regulatory roles under physiological and pathological conditions …
attention due to its broad regulatory roles under physiological and pathological conditions …
To Ub or not to Ub: Regulation of circadian clocks by ubiquitination and deubiquitination
SB Srikanta, N Cermakian - Journal of neurochemistry, 2021 - Wiley Online Library
Circadian clocks are internal timing systems that enable organisms to adjust their behavioral
and physiological rhythms to the daily changes of their environment. These clocks generate …
and physiological rhythms to the daily changes of their environment. These clocks generate …
CRL4Cdt2: coupling genome stability to ubiquitination
The cullin-RING E3 ubiquitin ligase CRL4 Cdt2 has emerged as a master regulator of
genome stability, which targets key cell cycle proteins for proteolysis during S phase and …
genome stability, which targets key cell cycle proteins for proteolysis during S phase and …
The fine-tuned crosstalk between lysine acetylation and the circadian rhythm
H Jiang, X Wang, J Ma, G Xu - Biochimica et Biophysica Acta (BBA)-Gene …, 2023 - Elsevier
Circadian rhythm is a roughly 24-h wake and sleep cycle that almost all of the organisms on
the earth follow when they execute their biological functions and physiological activities. The …
the earth follow when they execute their biological functions and physiological activities. The …
Death of a protein: The role of E3 ubiquitin ligases in circadian rhythms of mice and flies
OHMH Abdalla, B Mascarenhas… - International Journal of …, 2022 - mdpi.com
Circadian clocks evolved to enable organisms to anticipate and prepare for periodic
environmental changes driven by the day–night cycle. This internal timekee** mechanism …
environmental changes driven by the day–night cycle. This internal timekee** mechanism …
USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock
Mammalian Cryptochromes, CRY1 and CRY2, function as principal regulators of a
transcription-translation-based negative feedback loop underlying the mammalian circadian …
transcription-translation-based negative feedback loop underlying the mammalian circadian …
Molecular crosstalk between circadian rhythmicity and the development of neurodegenerative disorders
A Sharma, S Lee, H Kim, H Yoon, S Ha… - Frontiers in …, 2020 - frontiersin.org
Neurodegenerative disorders have been shown to exhibit substantial interconnectedness
with circadian rhythmicity. Alzheimer's patients exhibit high degradation of the …
with circadian rhythmicity. Alzheimer's patients exhibit high degradation of the …
Cullin 4-DCAF proteins in tumorigenesis
Abstract Cullin-RING ligase 4 (CRL4), a member of the cullin-RING ligase family,
orchestrates a variety of critical cellular processes and pathophysiological events. Recent …
orchestrates a variety of critical cellular processes and pathophysiological events. Recent …