Cells coordinate intracellular activities in response to changes in the extracellular
environment to maximize their probability of survival and proliferation. Eukaryotic cells need …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

Cell density shows very little variation within a given cell type. For example, in humans
variability in cell density among cells of a given cell type is 100 times smaller than variation …

The main focus in development of yeast cell factories has generally been on establishing
optimal activity of heterologous pathways and further metabolic engineering of the host …

Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit
many of the responses that are evoked in cells by changes in certain environmental …

A complete description of protein metabolism requires knowledge of the rates of protein
production and destruction within cells. Using an epitope-tagged strain collection, we …

Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, under certain environmental …

The resistance of Candida albicans to many stresses is dependent on the stress-activated
protein kinase (SAPK) Hog1. Hence we have explored the role of Hog1 in the regulation of …

Negative feedback can serve many different cellular functions, including noise reduction in
transcriptional networks and the creation of circadian oscillations. However, only one special …

Integration of experimental studies with mathematical modeling allows insight into systems
properties, prediction of perturbation effects and generation of hypotheses for further …