Epidemiology and outcome of glioblastoma
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. With an
incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 …
incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 …
Multicellular tumor spheroids: an underestimated tool is catching up again
F Hirschhaeuser, H Menne, C Dittfeld, J West… - Journal of …, 2010 - Elsevier
The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …
and cocultures for implementation into state of the art anti-cancer therapy test platforms …
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …
Application of proteomics in cancer: recent trends and approaches for biomarkers discovery
YW Kwon, HS Jo, S Bae, Y Seo, P Song, M Song… - Frontiers in …, 2021 - frontiersin.org
Proteomics has become an important field in molecular sciences, as it provides valuable
information on the identity, expression levels, and modification of proteins. For example …
information on the identity, expression levels, and modification of proteins. For example …
Cancer stem cells in glioblastoma
Tissues with defined cellular hierarchies in development and homeostasis give rise to
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …
GFAP in health and disease
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
[HTML][HTML] Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
E Kim, M Kim, DH Woo, Y Shin, J Shin, N Chang… - Cancer cell, 2013 - cell.com
Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …
TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma
Triggering receptor expressed on myeloid cells 2 (TREM2) plays important roles in brain
microglial function in neurodegenerative diseases, but the role of TREM2 in the GBM TME …
microglial function in neurodegenerative diseases, but the role of TREM2 in the GBM TME …
Fate map** of human glioblastoma reveals an invariant stem cell hierarchy
Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive
tumorigenesis. However, the origin of intratumoural functional heterogeneity between …
tumorigenesis. However, the origin of intratumoural functional heterogeneity between …