Triple negative breast cancer: molecular subtype-specific immune landscapes with therapeutic implications

A Syrnioti, S Petousis, LA Newman… - Cancers, 2024 - mdpi.com
Simple Summary Triple Negative Breast Cancer (TNBC) comprises approximately 15–20%
of all breast cancer (BC) cases, is often diagnosed at an advanced stage, and is generally …

[HTML][HTML] Navigating the immune maze: pioneering strategies for unshackling cancer immunotherapy resistance

L Yao, Q Wang, W Ma - Cancers, 2023 - mdpi.com
Simple Summary Cancer treatments have made remarkable advances with the introduction
of immunotherapy, which recruits the body's immune system to fight cancer. Despite these …

MDSCs in bone metastasis: mechanisms and therapeutic potential1

Z Li, Q **a, Y He, L Li, P Yin - Cancer Letters, 2024 - Elsevier
Bone metastasis (BM) is a frequent complication associated with advanced cancer that
significantly increases patient mortality. Myeloid-derived suppressor cells (MDSCs) play a …

[HTML][HTML] Mannan-Decorated Lipid Calcium Phosphate Nanoparticle Vaccine Increased the Antitumor Immune Response by Modulating the Tumor Microenvironment

L Wu, L Yang, X Qian, W Hu, S Wang… - Journal of Functional …, 2024 - mdpi.com
With the rapid development of tumor immunotherapy, nanoparticle vaccines have attracted
much attention as potential therapeutic strategies. A systematic review and analysis must be …

Hesperidin suppressed metastasis, angiogenesis and tumour growth in Balb/c mice model of breast cancer

E Shakiba, A Bazi, H Ghasemi… - Journal of Cellular …, 2023 - Wiley Online Library
Considering the unfavourable response of breast cancer (BC) to treatment, we assessed the
therapeutic potential hesperidin in mice bearing 4T1 BC tumours. Anti‐tumour effects were …

Inhibiting CXCR4 reduces immunosuppressive effects of myeloid cells in breast cancer immunotherapy

NG Ciavattone, A Bevoor, A Farfel, A Rehman… - Scientific Reports, 2025 - nature.com
Patients with triple negative breast cancer (TNBC) show only modest response rates to
immune checkpoint inhibitor immunotherapy, motivating ongoing efforts to identify …

Advancing cancer immunotherapy: from innovative preclinical models to clinical insights

AW Craig, HB Frieboes, PA Videira - Scientific Reports, 2024 - nature.com
The rapid expansion of cancer immunology and immunotherapy builds upon the success of
early immune checkpoint inhibitors (ICI) and chimeric antigen receptor T cells for some …

Patterns of immune evasion in triple-negative breast cancer and new potential therapeutic targets: a review

L Serrano García, B Jávega… - Frontiers in …, 2024 - frontiersin.org
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer
characterized by the absence of progesterone and estrogen receptors and low (or absent) …

An insight into the role of innate immune cells in breast tumor microenvironment

S Garg, G Rai, S Singh, P Gauba, J Ali, S Dang - Breast Cancer, 2024 - Springer
The immune background of breast cancer is highly heterogeneous and the immune system
of the human body plays a dual role by both promoting and suppressing its progression …

Tumor Microenvironment Modulation and Its Impact on Immunotherapy in Triple-Negative Breast Cancer

N Malkani, MU Rashid, A Ramzan, K Khalid - Breast Cancer Treatment …, 2024 - Springer
Triple-negative breast cancer (TNBC) is known as a refractory and inoperable breast cancer
subtype with the worst prognosis. The poor treatment response due to the lack of specific …