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Management of myocarditis-related cardiomyopathy in adults
Myocarditis is generally a mild and self-limited consequence of systemic infection of
cardiotropic viruses. However, patients can develop a temporary or permanent impairment …
cardiotropic viruses. However, patients can develop a temporary or permanent impairment …
Inflammatory cardiomyopathic syndromes
BH Trachtenberg, JM Hare - Circulation research, 2017 - ahajournals.org
Inflammatory activation occurs in nearly all forms of myocardial injury. In contrast,
inflammatory cardiomyopathies refer to a diverse group of disorders in which inflammation of …
inflammatory cardiomyopathies refer to a diverse group of disorders in which inflammation of …
Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy
In the past two decades, porous silicon (PSi) has attracted increasing attention for its
potential biomedical applications. With its controllable geometry, tunable nanoporous …
potential biomedical applications. With its controllable geometry, tunable nanoporous …
Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats
C Zhang, Y Cheng, D Liu, M Liu, H Cui, B Zhang… - Journal of …, 2019 - Springer
Abstract Background Cyclosporin A (CsA) is a promising therapeutic drug for myocardial
ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening of …
ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening of …
Nanoencapsulated quercetin improves cardioprotection during hypoxia‐reoxygenation injury through preservation of mitochondrial function
The effective delivery of antioxidants to the cells is hindered by their high metabolization
rate. In this work, quercetin was encapsulated in poly (lactic‐co‐glycolic) acid (PLGA) …
rate. In this work, quercetin was encapsulated in poly (lactic‐co‐glycolic) acid (PLGA) …
Update on myocarditis–what we know so far and where we may be heading
Myocarditis is defined as an inflammatory infiltration of the myocardium with associated
necrosis and/or degeneration, frequently resulting from different infectious or non-infectious …
necrosis and/or degeneration, frequently resulting from different infectious or non-infectious …
Mitochondrial Ca2+ Uniporter–Dependent Energetic Dysfunction Drives Hypertrophy in Heart Failure
The role of the mitochondrial calcium uniporter (MCU) in energy dysfunction and
hypertrophy in heart failure (HF) remains unknown. In angiotensin II (ANGII)–induced …
hypertrophy in heart failure (HF) remains unknown. In angiotensin II (ANGII)–induced …
Nanoscale technologies for prevention and treatment of heart failure: challenges and opportunities
The adult myocardium has a limited regenerative capacity following heart injury, and the lost
cells are primarily replaced by fibrotic scar tissue. Suboptimal efficiency of current clinical …
cells are primarily replaced by fibrotic scar tissue. Suboptimal efficiency of current clinical …
Mitochondria-targeted antioxidant delivery for precise treatment of myocardial ischemia–reperfusion injury through a multistage continuous targeted strategy
Y Cheng, D Liu, C Zhang, H Cui, M Liu, Q Mei… - … , Biology and Medicine, 2019 - Elsevier
Efficient delivery of antioxidant drugs into mitochondria of ischemic cardiomyocytes where
reactive oxygen species largely induced is a major challenge for precise treatment of …
reactive oxygen species largely induced is a major challenge for precise treatment of …
Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes
Background Silica nanoparticles (nanoSiO 2) are promising systems that can deliver
biologically active compounds to tissues such as the heart in a controllable manner …
biologically active compounds to tissues such as the heart in a controllable manner …