Management of myocarditis-related cardiomyopathy in adults

C Tschöpe, LT Cooper, G Torre-Amione… - Circulation …, 2019 - ahajournals.org
Myocarditis is generally a mild and self-limited consequence of systemic infection of
cardiotropic viruses. However, patients can develop a temporary or permanent impairment …

Inflammatory cardiomyopathic syndromes

BH Trachtenberg, JM Hare - Circulation research, 2017 - ahajournals.org
Inflammatory activation occurs in nearly all forms of myocardial injury. In contrast,
inflammatory cardiomyopathies refer to a diverse group of disorders in which inflammation of …

Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy

W Li, Z Liu, F Fontana, Y Ding, D Liu… - Advanced …, 2018 - Wiley Online Library
In the past two decades, porous silicon (PSi) has attracted increasing attention for its
potential biomedical applications. With its controllable geometry, tunable nanoporous …

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

C Zhang, Y Cheng, D Liu, M Liu, H Cui, B Zhang… - Journal of …, 2019 - Springer
Abstract Background Cyclosporin A (CsA) is a promising therapeutic drug for myocardial
ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening of …

Nanoencapsulated quercetin improves cardioprotection during hypoxia‐reoxygenation injury through preservation of mitochondrial function

O Lozano, A Lázaro-Alfaro… - Oxidative Medicine …, 2019 - Wiley Online Library
The effective delivery of antioxidants to the cells is hindered by their high metabolization
rate. In this work, quercetin was encapsulated in poly (lactic‐co‐glycolic) acid (PLGA) …

Update on myocarditis–what we know so far and where we may be heading

A Rroku, J Kottwitz, B Heidecker - European Heart Journal Acute …, 2021 - academic.oup.com
Myocarditis is defined as an inflammatory infiltration of the myocardium with associated
necrosis and/or degeneration, frequently resulting from different infectious or non-infectious …

Mitochondrial Ca2+ Uniporter–Dependent Energetic Dysfunction Drives Hypertrophy in Heart Failure

H Alves-Figueiredo, C Silva-Platas, M Estrada… - Basic to Translational …, 2024 - jacc.org
The role of the mitochondrial calcium uniporter (MCU) in energy dysfunction and
hypertrophy in heart failure (HF) remains unknown. In angiotensin II (ANGII)–induced …

Nanoscale technologies for prevention and treatment of heart failure: challenges and opportunities

MJ Hajipour, M Mehrani, SH Abbasi, A Amin… - Chemical …, 2019 - ACS Publications
The adult myocardium has a limited regenerative capacity following heart injury, and the lost
cells are primarily replaced by fibrotic scar tissue. Suboptimal efficiency of current clinical …

Mitochondria-targeted antioxidant delivery for precise treatment of myocardial ischemia–reperfusion injury through a multistage continuous targeted strategy

Y Cheng, D Liu, C Zhang, H Cui, M Liu, Q Mei… - … , Biology and Medicine, 2019 - Elsevier
Efficient delivery of antioxidant drugs into mitochondria of ischemic cardiomyocytes where
reactive oxygen species largely induced is a major challenge for precise treatment of …

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

O Lozano, C Silva-Platas, H Chapoy-Villanueva… - Particle and Fibre …, 2020 - Springer
Background Silica nanoparticles (nanoSiO 2) are promising systems that can deliver
biologically active compounds to tissues such as the heart in a controllable manner …