Nitric oxide: physiological functions, delivery, and biomedical applications

SM Andrabi, NS Sharma, A Karan… - Advanced …, 2023 - Wiley Online Library
Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …

The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

MA Incalza, R D'Oria, A Natalicchio, S Perrini… - Vascular …, 2018 - Elsevier
Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as
important second messengers within the cells; however, an imbalance between generation …

Nitric oxide signalling in cardiovascular health and disease

C Farah, LYM Michel, JL Balligand - Nature Reviews Cardiology, 2018 - nature.com
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

[HTML][HTML] Dysfunctional and dysregulated nitric oxide synthases in cardiovascular disease: mechanisms and therapeutic potential

R Roy, J Wilcox, AJ Webb, K O'Gallagher - International journal of …, 2023 - mdpi.com
Nitric oxide (NO) plays an important and diverse signalling role in the cardiovascular system,
contributing to the regulation of vascular tone, endothelial function, myocardial function …

Endothelial cell metabolism

G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

The superoxide radical switch in the biology of nitric oxide and peroxynitrite

L Piacenza, A Zeida, M Trujillo… - Physiological …, 2022 - journals.physiology.org
The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

[HTML][HTML] Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

P Guerby, O Tasta, A Swiader, F Pont, E Bujold… - Redox biology, 2021 - Elsevier
Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset
gestational hypertension with (or without) proteinuria or end-organ failure, exclusively …

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

SP Wang, R Chennupati, H Kaur, A Iring… - The Journal of clinical …, 2016 - jci.org
Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are
released from the endothelium under the influence of fluid shear stress exerted by flowing …