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Nitric oxide: physiological functions, delivery, and biomedical applications
Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …
involved in numerous physiological processes (eg, vasodilation, neurotransmission …
The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
Sources of vascular nitric oxide and reactive oxygen species and their regulation
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases
MA Incalza, R D'Oria, A Natalicchio, S Perrini… - Vascular …, 2018 - Elsevier
Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as
important second messengers within the cells; however, an imbalance between generation …
important second messengers within the cells; however, an imbalance between generation …
Nitric oxide signalling in cardiovascular health and disease
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
[HTML][HTML] Dysfunctional and dysregulated nitric oxide synthases in cardiovascular disease: mechanisms and therapeutic potential
Nitric oxide (NO) plays an important and diverse signalling role in the cardiovascular system,
contributing to the regulation of vascular tone, endothelial function, myocardial function …
contributing to the regulation of vascular tone, endothelial function, myocardial function …
Endothelial cell metabolism
G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …
active players in the formation of new blood vessels (angiogenesis) both in health and (life …
The superoxide radical switch in the biology of nitric oxide and peroxynitrite
L Piacenza, A Zeida, M Trujillo… - Physiological …, 2022 - journals.physiology.org
The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …
[HTML][HTML] Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia
Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset
gestational hypertension with (or without) proteinuria or end-organ failure, exclusively …
gestational hypertension with (or without) proteinuria or end-organ failure, exclusively …
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
Arterial blood pressure is controlled by vasodilatory factors such as nitric oxide (NO) that are
released from the endothelium under the influence of fluid shear stress exerted by flowing …
released from the endothelium under the influence of fluid shear stress exerted by flowing …