Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …

Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting
and degrading aging proteins and damaged organelles. The effect of autophagy on neural …

Enhancing the removal of aggregate-prone toxic proteins is a rational therapeutic strategy
for a number of neurodegenerative diseases, especially Huntington's disease and various …

Abstract Parkinson's disease (PD), a common human neurodegenerative disorder, is
characterized by the presence of intraneuronal Lewy bodies composed principally of …

Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder, the important pathology of PD due to the prominent loss of the dopaminergic …

SMER28 originated from a screen for small molecules that act as modulators of autophagy.
SMER28 enhanced the clearance of autophagic substrates such as mutant huntingtin, which …

Introduction: Parkinson's disease (PD) is a progressive and severe neurodegenerative
disorder of the central nervous system (CNS). The most prominent features of this disease …

Methamphetamine (METH) can potentially disrupt neurotransmitters activities in the central
nervous system (CNS) and cause neurotoxicity through various pathways. These pathways …

Introduction: In men, several factors cause infertility, among which we can mention damage
to sperm due to high temperature. So far, various treatments have been proposed for it, but …

Berberine, an isoquinoline alkaloid isolated from Coptis chinensis, has been widely studied
for its efficacy in the treatment of neurodegenerative diseases. However, the detailed …