Medicinal chemical approaches have been applied to all four of the adenosine receptor
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …

The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to
display a variety of biological activities. Thiazole and its derivatives have attracted …

Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …

Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …

This Review summarizes and updates the work on adenosine A2A receptor antagonists for
Parkinson's disease from 2006 to the present. There have been numerous publications …

A novel small molecule based on benzothiazole-piperazine has been identified as an
effective multi-target-directed ligand (MTDL) against Alzheimer's disease (AD). Employing a …

Parkinson's disease (PD) is the second common neurodegenerative disease characterized
by movement disorder. The symptoms of PD harm both the physical and mental health of …

Like nitrogen‐containing heterocycles, sulfur‐containing heterocyclic compounds also have
a lot of significant applications. These sulfur heterocycles are mainly used as a core for the …

Black berry (Syzygium cumini) fruit is useful in curing diabetic complications; however, its
role in diabetes‐induced cardiomyopathy is not yet known. In this study, we investigated the …