Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021‏ - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Therapeutic interventions in patients with prolonged disorders of consciousness

A Thibaut, N Schiff, J Giacino, S Laureys… - The Lancet …, 2019‏ - thelancet.com
The management of patients with severe brain injuries and prolonged disorders of
consciousness raises important issues particularly with respect to their therapeutic options …

Robust EEG-based cross-site and cross-protocol classification of states of consciousness

DA Engemann, F Raimondo, JR King, B Rohaut… - Brain, 2018‏ - academic.oup.com
Determining the state of consciousness in patients with disorders of consciousness is a
challenging practical and theoretical problem. Recent findings suggest that multiple markers …

Prognosis for patients with cognitive motor dissociation identified by brain-computer interface

J Pan, Q **e, P Qin, Y Chen, Y He, H Huang, F Wang… - Brain, 2020‏ - academic.oup.com
Cognitive motor dissociation describes a subset of patients with disorders of consciousness
who show neuroimaging evidence of consciousness but no detectable command-following …

The neuroethics of disorders of consciousness: a brief history of evolving ideas

MJ Young, YG Bodien, JT Giacino, JJ Fins, RD Truog… - Brain, 2021‏ - academic.oup.com
Neuroethical questions raised by recent advances in the diagnosis and treatment of
disorders of consciousness are rapidly expanding, increasingly relevant and yet …

Coma prognostication after acute brain injury: a review

D Fischer, BL Edlow - JAMA neurology, 2024‏ - jamanetwork.com
Importance Among the most impactful neurologic assessments is that of
neuroprognostication, defined here as the prediction of neurologic recovery from disorders …

Cognitive motor dissociation: gap analysis and future directions

J Claassen, D Kondziella, A Alkhachroum, M Diringer… - Neurocritical care, 2024‏ - Springer
Background Patients with disorders of consciousness who are behaviorally unresponsive
may demonstrate volitional brain responses to motor imagery or motor commands …

Minimally conscious state or cortically mediated state?

L Naccache - Brain, 2018‏ - academic.oup.com
Durable impairments of consciousness are currently classified in three main neurological
categories: comatose state, vegetative state (also recently coined unresponsive wakefulness …

Multimodal assessment improves neuroprognosis performance in clinically unresponsive critical-care patients with brain injury

B Rohaut, C Calligaris, B Hermann, P Perez… - Nature Medicine, 2024‏ - nature.com
Accurately predicting functional outcomes for unresponsive patients with acute brain injury is
a medical, scientific and ethical challenge. This prospective study assesses how a …

Neuroprognostication: a conceptual framework

D Fischer, BL Edlow, JT Giacino… - Nature Reviews Neurology, 2022‏ - nature.com
Neuroprognostication, or the prediction of recovery from disorders of consciousness caused
by severe brain injury, is as critical as it is complex. With profound implications for mortality …