Ferritinophagy: research advance and clinical significance in cancers

J Wang, N Wu, M Peng, L Oyang, X Jiang, Q Peng… - Cell Death …, 2023 - nature.com
Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear
receptor coactivator 4 (NCOA4), entails the recognition of ferritin by NCOA4 and subsequent …

Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool

CC Philpott, O Protchenko, Y Wang… - Frontiers in Molecular …, 2023 - frontiersin.org
Cells express hundreds of iron-dependent enzymes that rely on the iron cofactors heme,
iron-sulfur clusters, and mono-or di-nuclear iron centers for activity. Cells require systems for …

Extracellular NCOA4 is a mediator of septic death by activating the AGER-NFKB pathway

J Liu, Y Wang, L Zeng, C Yu, R Kang, DJ Klionsky… - Autophagy, 2024 - Taylor & Francis
Sepsis, a life-threatening condition resulting from a dysregulated response to pathogen
infection, poses a significant challenge in clinical management. Here, we report a novel role …

Cellular zinc deficiency impairs heme biosynthesis in develo** erythroid progenitors

J Kim, J Lee, MS Ryu - Nutrients, 2023 - mdpi.com
Anemia is the most prevalent nutrition-related disorder worldwide. Zinc is an essential trace
element for various biological processes in the body, and zinc deficiency has been …

Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer

J Hwang, A Park, C Kim, CG Kim, J Kwak, B Kim… - Cell Communication and …, 2024 - Springer
Background Dysregulation of iron metabolism is implicated in malignant transformation,
cancer progression, and therapeutic resistance. Here, we demonstrate that iron regulatory …

Quantitative omics analyses of NCOA4 deficiency reveal an integral role of ferritinophagy in iron homeostasis of hippocampal neuronal HT22 cells

EF Bengson, CA Guggisberg, TW Bastian… - Frontiers in …, 2023 - frontiersin.org
Introduction Neurons require iron to support their metabolism, growth, and differentiation, but
are also susceptible to iron-induced oxidative stress and cytotoxicity. Ferritin, a cytosolic iron …

Chondrocyte Ferritinophagy as a Molecular Mechanism of Arthritis–A Narrative Review

Y Liu, C Song, S Gao, D Zhou, J Lv, Y Zhou… - Cell Biochemistry and …, 2024 - Springer
Osteoarthritis (OA) is a prevalent joint disease affecting orthopedic patients. Its incidence is
steadily increasing, causing great economic hardship for individuals and society as a whole …

A novel brick on the wall of non-alcoholic fatty liver disease (NAFLD): Nuclear receptor coactivator 4 (NCOA4)

M Ucdal, A Burus, B Celtikci, HY Balaban - Medical Hypotheses, 2023 - Elsevier
Dysmetabolic iron overload syndrome (DIOS) defines a moderate increase in body iron load
in the absence of an identifiable cause of iron excess, and one of its main target organs is …

Copper ferrite obtaining from microelectronics waste

АС Новиков, ЕА Сударев… - Bulletin of the Tomsk …, 2023 - izvestiya.tpu.ru
Аннотация Актуальность исследования обусловлена необходимостью разработки
новых методик по утилизации металлических отходов. Данное направление, при …

[PDF][PDF] Физико-химические закономерности жидкофазных процессов переработки отходов, содержащих Al, Fe, Cu: диссертация на соискание ученой степени …

АС Новиков - 2024 - earchive.tpu.ru
Актуальность работы. В ходе химической переработки алюминиевых отходов
возможно получение множества полезных для промышленности продуктов. Водород …