Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review

S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …

Resistance development to bacteriophages occurring during bacteriophage therapy

F Oechslin - Viruses, 2018 - mdpi.com
Bacteriophage (phage) therapy, ie, the use of viruses that infect bacteria as antimicrobial
agents, is a promising alternative to conventional antibiotics. Indeed, resistance to antibiotics …

[HTML][HTML] Phage therapy as a potential solution in the fight against AMR: obstacles and possible futures

C Brives, J Pourraz - Palgrave Communications, 2020 - nature.com
Phage therapy, the use of bacteriophage viruses to treat bacterial infections, has existed for
more than a hundred years. However, the practice is struggling to develop, despite growing …

[HTML][HTML] Phage therapy in the resistance era: where do we stand and where are we going?

T Luong, AC Salabarria, DR Roach - Clinical therapeutics, 2020 - Elsevier
Purpose Widespread antibiotic-resistant bacteria are threatening the arsenal of existing
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …

Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth

ST Abedon, KM Danis-Wlodarczyk, DJ Wozniak - Pharmaceuticals, 2021 - mdpi.com
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …

Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

K Dąbrowska - Medicinal research reviews, 2019 - Wiley Online Library
Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …

The magistral phage

JP Pirnay, G Verbeken, PJ Ceyssens, I Huys, D De Vos… - Viruses, 2018 - mdpi.com
Since time immemorial, phages—the viral parasites of bacteria—have been protecting
Earth's biosphere against bacterial overgrowth. Today, phages could help address the …

Antibiotic alternatives: the substitution of antibiotics in animal husbandry?

G Cheng, H Hao, S **e, X Wang, M Dai… - Frontiers in …, 2014 - frontiersin.org
It is a common practice for decades to use of sub-therapeutic dose of antibiotics in food-
animal feeds to prevent animals from diseases and to improve production performance in …