RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2,
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …

Enhancer elements are a key regulatory feature of many important genes. Several general
features including the presence of specific histone modifications are used to demarcate …

Enhancers are DNA sequences that enable complex temporal and tissue-specific regulation
of genes in higher eukaryotes. Although it is not entirely clear how enhancer-promoter …

BRD4, a major tandem-bromodomain-containing transcription regulator, has two isoforms.
The long isoform (BRD4L) has an extended C terminus that binds transcription cofactors …

Abstract Background The Mnk2 kinase, encoded by MKNK2 gene, plays critical roles in
MAPK signaling and was involved in oncogenesis. Human MKNK2 pre-mRNA can be …

Aberrant enhancer activation is a key mechanism driving oncogene expression in many
cancers. While much is known about the regulation of larger chromosome domains in …

Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a
major challenge for clinicians and patients with non-small cell lung cancer (NSCLC). Serine …

Approximately half of genetic disease-associated mutations cause aberrant splicing.
However, a widely applicable therapeutic strategy to splicing diseases is yet to be …

Lung cancer, including non-small cell lung carcinoma (NSCLC), is the most frequently
diagnosed cancer. It is also the leading cause of cancer-related mortality worldwide …