Obesity, type 2 diabetes, and cancer risk
T Scully, A Ettela, D LeRoith, EJ Gallagher - Frontiers in oncology, 2021 - frontiersin.org
Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …
Natural small molecules in breast cancer treatment: understandings from a therapeutic viewpoint
MR Islam, F Islam, MH Nafady, M Akter, S Mitra, R Das… - Molecules, 2022 - mdpi.com
Breast cancer (BrCa) is the most common malignancy in women and the second most
significant cause of death from cancer. BrCa is one of the most challenging malignancies to …
significant cause of death from cancer. BrCa is one of the most challenging malignancies to …
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence,
while the use of statins, cholesterol biosynthesis inhibitors widely used for treating …
while the use of statins, cholesterol biosynthesis inhibitors widely used for treating …
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
Hypercholesterolemia is a risk factor for estrogen receptor (ER)–positive breast cancers and
is associated with a decreased response of tumors to endocrine therapies. Here, we show …
is associated with a decreased response of tumors to endocrine therapies. Here, we show …
[HTML][HTML] Alterations in cholesterol metabolism as a risk factor for develo** Alzheimer's disease: Potential novel targets for treatment
Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …
Estrogenic endocrine disruptors: Molecular mechanisms of action
R Kiyama, Y Wada-Kiyama - Environment International, 2015 - Elsevier
A comprehensive summary of more than 450 estrogenic chemicals including estrogenic
endocrine disruptors is provided here to understand the complex and profound impact of …
endocrine disruptors is provided here to understand the complex and profound impact of …
[HTML][HTML] The role of mitochondrial dysfunction in age-related diseases
RK Lane, T Hilsabeck, SL Rea - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The aging process is accompanied by the onset of disease and a general decline in
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …
Cholesterol and breast cancer pathophysiology
Cholesterol is a risk factor for breast cancer although the mechanisms by which this occurs
are not well understood. One hypothesis is that dyslipidemia results in increased cholesterol …
are not well understood. One hypothesis is that dyslipidemia results in increased cholesterol …
Updating the role of obesity and cholesterol in breast cancer
L Garcia-Estevez, G Moreno-Bueno - Breast Cancer Research, 2019 - Springer
Background Breast cancer is the second most common cause of cancer-related death
among women. Advances in our understanding of the disease have translated into better …
among women. Advances in our understanding of the disease have translated into better …
Involvement of oxysterols in age-related diseases and ageing processes
Ageing is accompanied by increasing vulnerability to major pathologies (atherosclerosis,
Alzheimer's disease, age-related macular degeneration, cataract, and osteoporosis) which …
Alzheimer's disease, age-related macular degeneration, cataract, and osteoporosis) which …