Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …

Next-generation transcriptome assembly

JA Martin, Z Wang - Nature Reviews Genetics, 2011 - nature.com
Transcriptomics studies often rely on partial reference transcriptomes that fail to capture the
full catalogue of transcripts and their variations. Recent advances in sequencing …

Transcriptomic and genetic analysis of direct interspecies electron transfer

PM Shrestha, AE Rotaru, ZM Summers… - Applied and …, 2013 - Am Soc Microbiol
The possibility that metatranscriptomic analysis could distinguish between direct
interspecies electron transfer (DIET) and H2 interspecies transfer (HIT) in anaerobic …

Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition

Y Ramayo-Caldas, N Mach, A Esteve-Codina… - BMC genomics, 2012 - Springer
Background New advances in high-throughput technologies have allowed for the massive
analysis of genomic data, providing new opportunities for the characterization of the …

Analysis of porcine adipose tissue transcriptome reveals differences in de novo fatty acid synthesis in pigs with divergent muscle fatty acid composition

J Corominas, Y Ramayo-Caldas, A Puig-Oliveras… - BMC genomics, 2013 - Springer
Background In pigs, adipose tissue is one of the principal organs involved in the regulation
of lipid metabolism. It is particularly involved in the overall fatty acid synthesis with …

Differential gene expression in ovaries of Qira black sheep and Hetian sheep using RNA-Seq technique

HY Chen, H Shen, B Jia, YS Zhang, XH Wang… - PloS one, 2015 - journals.plos.org
The Qira black sheep and the Hetian sheep are two local breeds in the Northwest of China,
which are characterized by high-fecundity and low-fecundity breed respectively. The …

An RNA‐seq protocol to identify mRNA expression changes in mouse diaphyseal bone: Applications in mice with bone property altering Lrp5 mutations

UM Ayturk, CM Jacobsen… - Journal of Bone and …, 2013 - academic.oup.com
Loss‐of‐function and certain missense mutations in the Wnt coreceptor low‐density
lipoprotein receptor‐related protein 5 (LRP5) significantly decrease or increase bone mass …

Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative …

D Lee-Liu, M Moreno, LI Almonacid, VS Tapia… - Neural …, 2014 - Springer
Background Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it
is fully capable of functional recovery after a spinal cord injury, while its juvenile form …

RNA-sequencing: a tool to explore new frontiers in animal genetics

S Wickramasinghe, A Cánovas, G Rincón, JF Medrano - Livestock Science, 2014 - Elsevier
Global gene expression profiling by RNA-Sequencing (RNA-Seq) was introduced in 2004
with the advent of next generation sequencing technologies and has made a revolutionary …

Genome-wide mRNA-seq profiling reveals predominant down-regulation of lipid metabolic processes in adipose tissues of Small Tail Han than Dorset sheep

X Miao, Q Luo, X Qin, Y Guo, H Zhao - Biochemical and biophysical …, 2015 - Elsevier
Abstract Small Tail Han and Dorset sheep are two different sheep with distinguished
morphologies in fat depositions. In order to characterize their gene expression profiles, our …