PIEZO Ion Channels in Cardiovascular Functions and Diseases

B Coste, P Delmas - Circulation Research, 2024 - Am Heart Assoc
The cardiovascular system provides blood supply throughout the body and as such is
perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with …

[HTML][HTML] Exercise-driven cellular autophagy: A bridge to systematic wellness

XH Zhou, YX Luo, XQ Yao - Journal of Advanced Research, 2025 - Elsevier
Background Exercise enhances health by supporting homeostasis, bolstering defenses, and
aiding disease recovery. It activates autophagy, a conserved cellular process essential for …

Effects of Panax notoginseng saponins on alleviating low shear induced endothelial inflammation and thrombosis via Piezo1 signalling

L Liu, J Li, Y Wang, P Gong, J Feng, S **ao, J Xu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Panax notoginseng saponins (PNS) are the major
effective components of Panax notoginseng (burk) FH Chen which is one of the classic …

A review on decoding the roles of YAP/TAZ signaling pathway in cardiovascular diseases: Bridging molecular mechanisms to therapeutic insights

Y Zhang, Y Ren, X Li, M Li, M Fu, W Zhou, Y Yu… - International Journal of …, 2024 - Elsevier
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
serve as transcriptional co-activators that dynamically shuttle between the cytoplasm and …

[HTML][HTML] Single-Cell Hypertrophy Promotes Contractile Function of Cultured Human Airway Smooth Muscle Cells via Piezo1 and YAP Auto-Regulation

K Ni, B Che, R Gu, C Wang, Y Pan, J Li, L Liu, M Luo… - Cells, 2024 - mdpi.com
Severe asthma is characterized by increased cell volume (hypertrophy) and enhanced
contractile function (hyperresponsiveness) of the airway smooth muscle cells (ASMCs). The …

GsMTx4 Combined with Exercise Exerts Neuroprotective Effects by Regulating Neuronal Autophagy in Rats with Spinal Cord Injury

Q Li, C Li, X Li, X Liu, J Qian, J Li, X Li… - Neurochemical Research, 2025 - Springer
A sharp increase in intramedullary pressure after spinal cord injury (SCI) can aggravate
secondary injury and lead to severe neurological deficits. Unfortunately, effective treatment …

FNDC5 alleviates Ox-LDL-induced HUVECs dysfunction by inhibiting ferroptosis through AMPK/Nrf2 signaling

Y Du, H Ouyang, H Wang, J Shi, Y Li, L Xu, C He… - Tissue and Cell, 2025 - Elsevier
Background Endothelial cell dysfunction is the initial stage of atherosclerosis (AS). FNDC5
has been shown to play a role in the progression of AS and can regulate endothelial cell …

[HTML][HTML] Overexpression of Neural Precursor Cell Expressed Developmentally Downregulated 9 (NEDD9) reduces ox-LDL-induced Anoikis in atherosclerotic vascular …

X Zhou, Q Hu, M Yu, K Li - IJC Heart & Vasculature, 2025 - Elsevier
Objective This study purposes to explore the action of the Anoikis gene in vascular
endothelial cell injury, explore diagnostic biomarkers, and provide new insights into …

Oxidative Modulation of Piezo1 Receptors

N Novosolova, N Braidotti, T Patinen, T Laitinen… - Available at SSRN … - papers.ssrn.com
Emerging evidence suggests involvement of mechanosensitive Piezo1 receptors in the
pathomechanism of neurodegenerative disorders, including Alzheimer's Disease (AD) …

Overexpression of Nedd9 Reduces Ox-Ldl-Induced Anoikis in Atherosclerotic Vascular Endothelial Cells

X Zhou, M Yu, K Li - Available at SSRN 4984018 - papers.ssrn.com
ObjectiveThis study purposes to explore the action of the Anoikis gene in vascular
endothelial cell injury, explore diagnostic biomarkers, and provide new insights into …