Despite decades of research, cancer continues to be a major global health concern. The
human mouth appears to be a multiplicity of local environments communicating with other …

An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Objective The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing.
Here, we aimed to characterise the interactions between gut microbiome, metabolites and …

Colorectal cancer (CRC) is a substantial source of global morbidity and mortality in dire
need of improved prevention and treatment strategies. As our understanding of CRC grows …

Recent evidence suggests that some human cancers may harbor low-biomass microbial
ecosystems, spanning bacteria, viruses, and fungi. Bacteria, the most-studied kingdom in …

Intratumor microbiome shapes the immune system and influences the outcome of various
tumors. Porphyromonas gingivalis (P. gingivalis), the keystone periodontal pathogen, is …

Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of
resectable esophageal squamous cell carcinoma (ESCC). The microbiomes of patients can …

Background Colorectal cancer (CRC) is the third most common cancer in the world, and a
strong relationship exists between CRC and gut microbiota, which affects the occurrence …

Targeted therapy and immunotherapy have brought hopes for precision cancer treatment.
However, complex physiological barriers and tumor immunosuppression result in poor …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer mortality worldwide. Colitis-associated colorectal cancer (CAC) is a subtype …