Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
Hydroxyurea—the good, the bad and the ugly
MW Musiałek, D Rybaczek - Genes, 2021 - mdpi.com
Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …
Ribonucleotide reductases: structure, chemistry, and metabolism suggest new therapeutic targets
Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …
Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
Accurate DNA replication and repair is essential for proper development, growth and tumor-
free survival in all multicellular organisms. A key requirement for the maintenance of …
free survival in all multicellular organisms. A key requirement for the maintenance of …
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome
Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of
viral nucleic acid sequences. Properties of the host response are not measured but are key …
viral nucleic acid sequences. Properties of the host response are not measured but are key …
[KIRJA][B] Handbook of vitamins
J Zempleni, JW Suttie, JF Gregory III, PJ Stover - 2013 - books.google.com
Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …
edition of a bestseller presents comprehensive summaries that analyze the chemical …
Ribonucleotide reductases: essential enzymes for bacterial life
E Torrents - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of
deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This …
deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This …
A critical balance: dNTPs and the maintenance of genome stability
A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate
(dNTP) levels within a range that is optimal for chromosomal replication. Since DNA …
(dNTP) levels within a range that is optimal for chromosomal replication. Since DNA …
LINE-1 protein localization and functional dynamics during the cell cycle
LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …