The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …

Environmental and occupational exposure to cadmium has been shown to induce kidney
damage, liver injury, neurodegenerative disease, and osteoporosis. However, the …

Ataxia-telangiectasia mutated (ATM) is a master kinase regulating DNA damage response
that is activated by DNA double-strand breaks. However, ATM is also directly activated by …

Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of
defense have evolved to reduce the accumulation of DNA damage, including reducing …

Ataxia telangiectasia mutated (ATM) is a central kinase that activates an extensive network
of responses to cellular stress via a signaling role. ATM is activated by DNA double strand …

Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer.
Mitochondria are an important source of ROS; however, the spatiotemporal ROS events …

The ataxia telangiectasia mutated (ATM) protein kinase is best known as a master regulator
of the DNA damage response. However, accumulating evidence has unveiled an equally …

Small-cell lung cancer, a highly malignant form of lung cancer, often responds to first-line
treatments but relapses in most cases with resistance to further treatments. We tested zinc …

Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential
events. To ensure the dynamic nature of these molecular and morphological transitions, a …

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range
of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein …