Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Naphthoquinones are compounds present in several families of higher plants. Their
molecular structures confer redox properties, and they are involved in multiple biological …

Background Leishmaniasis, a parasitic disease caused by protozoa of the genus
Leishmania, affects more than 12 million people worldwide. Quercetin has generated …

The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania
spp. are the causative agents of African trypanosomiasis, Chagas disease, and …

Autophagy is the degradative process by which eukaryotic cells digest their own
components using acid hydrolases within the lysosome. Originally thought to function almost …

Electron microscopy has proven to be a reliable and essential tool to determine
morphological alterations and target organelles in the investigation of new drugs for Chagas …

Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Eukaryotic cells can degrade their own components, cytosolic proteins and organelles,
using dedicated hydrolases contained within the acidic interior of their lysosomes. This …

Apoptosis is a normal component of the development and health of multicellular organisms.
However, apoptosis is now considered a prerogative of unicellular organisms, including the …

[1, 2, 3]-Triazole derivatives of nor-β-lapachone were synthesized and assayed against the
infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of …